Enabling multi factor authentication (MFA) in Office 365 is best practice, especially for global administrators. However, doing so can raise some challenges when it comes to working with PowerShell command line and the ISE.
The above video tutorial takes you through the process of accessing your Office 365 tenant when you have MFA enabled. The commands that you need to also do this via the PowerShell ISE are here:
Import-Module $((Get-ChildItem -Path $($env:LOCALAPPDATA+”\Apps\2.0\”) -Filter Microsoft.Exchange.Management.ExoPowershellModule.dll -Recurse ).FullName|?{$_ -notmatch “_none_”}|select -First 1)
$EXOSession = New-ExoPSSession
Import-PSSession $EXOSession
Now you can still have MFA enabled on your accounts while using PowerShell. Yes, there is more work to enable this but if it is harder then generally you know it is more secure!
CIAOPS 